Development of smart alginate/chitosan grafted microcapsules for colon site-specific drug delivery

Site-specific Drug Delivery: Polymers for Gastroretention

Gastroretention is the mechanism by which a dosage form is retained in the stomach, generally for the purposes of improving drug delivery. It has been proposed as a mechanism through which drug absorption in the upper gastrointestinal tract can be maximised. Gastroretentive approaches to drug delivery aim to counteract the physiological mechanisms that cause the stomach to empty by providing a ...

role of polysaccharides in colon-specific drug delivery

Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon.

The ability to deliver drugs to the human colon in a specific manner has become feasible over the years. Targeting pharmaceutical drugs to the colon makes it possible to achieve local or systemic drug delivery to this site. To deliver the compounds in a non-degraded form to the lower part of the gastrointestinal tract, they must first of all pass through the stomach, the upper part of the intes...

Mechano-activatable Microcapsules for Tunable Drug Delivery

Introduction A particularly desirable feature of controlled drug delivery is self-regulation, wherein physiological feedback actively regulates release kinetics. Extant systems in this domain commonly employ stimuli-responsive vehicles that rely on internal triggers to precipitate release, such as temperature, pH, or chemical reactions. 2 The sensitivity of these triggers can be tuned by biomat...

Precision Medicine and Site-Specific Drug Delivery

Precision medicine is an approach to prevent and treat diseases that takes into account people’s individual variations in genes, environment, and lifestyle. The current Precision Medicine Initiative of the US Government is to “generate the scientific evidence needed to move the concept of precision medicine into clinical practice”. In the first approximation, precision medicine may provide a mo...